- Smith's Service Station
- Smokey's Diver's Den
- Snavely JC & Sons Inc
- Sneaker Villa
- Snippers
- Snoberger Service Co
- Snyder Crafts
- Software Research Group
- Solanco Lock & Safe Co
- Soloff & Zervanos
- Sona Sunoco
- Sonia Rose
- Sonotone Of Lancaster
- Soothing Touch Day Spa
- Soothing Touch Day Spa
- Sosangelis Jewelers